les publis

Blain J, Bédard J, Thompson M, Boisvert FM and Boucher MJ (2017) C-terminal deletion of NOTCH1 intracellular domain (N1ICD) increases its stability but does not amplify and recapitulate N1ICD-dependent signalling. Scientific Reports 7:5034.

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Klionsky DJ et al.(including Boucher MJ) (2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12(1) :1-222.

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Marchand B, Arsenault D, Raymond-Fleury A, Boisvert FM, and Boucher MJ (2015) Glycogen Synthase Kinase-3 (GSK3) inhibition induces pro-survival autophagic signals in human pancreatic cancer cells. J. Biol. Chem. 290 (9): 5592-5605. 

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Tremblay I, Paré E, Arsenault D, Douziech M, and Boucher MJ (2013) The MEK/ERK pathway promotes NOTCH signaling in pancreatic cancer cells. PLOS ONE 8 (12): e85502.

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Cagnol S, Boucher MJ, Carrier JC, and Rivard N (2012) Activation aberrante de la signalisation KRas/BRaf/MAP kinase dans les cancers pancréatiques et colorectaux. Médecine Sciences Amérique 1 (4): 86-103.

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Marchand B, Tremblay I, Cagnol S, and Boucher MJ (2012) Inhibition of glycogen synthase kinase-3 triggers an apoptotic response in pancreatic cancer cells through JNK-dependent mechanisms. Carcinogenesis 33:529-537.

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Lemieux E, Boucher MJ, Mongrain S, Boudreau F, Asselin C, and Rivard N (2011) Constitutive activation of the Mek/Erk pathway inhibits intestinal epithelial cell differentiation. Am. J. Physiol. 301 (4):G719-G730. 

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Bergeron S, Lemieux E, Durand V, Cagnol S, Carrier JC, Lussier JG, Boucher MJ, and Rivard N. (2010) The serine protease inhibitor SerpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis. Mol. Cancer 9:271. 

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Mysliwiec P, and Boucher MJ (2009) Targeting Notch signalling in pancreatic cancer patients – rationale for new therapy. Adv. Med. Sci. 54:136-142.

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Boucher MJ, Simoneau M, and Edlund H (2009) The homeodomain-interacting protein kinase 2 (HIPK2) regulates IPF1/PDX1 transcriptional activity. Endocrinology 150:87-97. 

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Boucher MJ, Selander L, Carlsson L, and Edlund H (2006) Phosphorylation marks IPF1/PDX1 protein for degradation by GSK3-dependent mechanisms. J. Biol. Chem. 281 (10):6395-6403. 

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Boucher MJ, Laprise P, and Rivard N (2005) Cyclic AMP-dependent protein kinase A negatively modulates adherens junction integrity and differentiation of intestinal epithelial cells. J. Cell. Physiol. 202 (1):178-90. 

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Boucher MJ, Jean D, Vézina A, and Rivard N (2004) Dual role of MEK/ERK signaling in senescence and transformation of intestinal epithelial cells. Am. J. Physiol. 286 (5): G736-G746. 

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Boucher MJ, and Rivard N (2003) Regulation and role of brush border-associated Erk1/2 in intestinal epithelial cells.Biochem. Biophys. Res. Comm. 311 (1): 121-128. 

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Laprise P, Langlois MJ, Boucher MJ, Jobin C, and Rivard N (2003) Down-regulation of MEK/ERK signaling by E-cadherin-dependent PI-3K/AKT pathway in differentiating intestinal epithelial cells. J. Cell. Physiol. 199 (1): 32-39. 

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Laprise P, Chailler P, Houde M, Beaulieu JF, Boucher MJ, and Rivard N (2002) Phosphatidylinositol 3-kinase controls intestinal epithelial cell differentiation by promoting adherens junctions assembly and p38 MAPK activation. J. Biol. Chem. 277 (10): 8226-8234. 

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Boucher MJ, Duchesne C, Lainé J, Morisset J, and Rivard N (2001) cAMP protection of pancreatic cancer cells against apoptosis induced by ERK inhibition. Biochem. Biophys. Res. Comm. 285 (2): 207-216. 

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Charland S, Boucher MJ, Houde M, and Rivard N (2001) Somatostatin inhibits phosphorylation and cell cycle entry, but not p42/p44 mitogen-activated protein (MAP) kinase activation in normal and tumoral pancreatic acinar cells. Endocrinology 142 (1): 121-128. 

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Boucher MJ, Morisset J, Vachon PH, Reed JC, and Rivard N (2000) The MEK/ERK signalling pathway regulates survival of human pancreatic cancer cells. J. Cell. Biochem. 79 (3): 355-369. 

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Rivard N, Boucher MJ, Asselin C, and L’Allemain G (1999) MAP kinase cascade is required for p27 down-regulation and S-phase entry in fibroblasts and epithelial cells. Am. J. Physiol. 277: C652-C664.